GUELPH, Ontario — Avocados are a dietary staple of millions, but a new study finds these delicious fruits may have some extra medicinal benefits to offer as well. Researchers from the University of Guelph have discovered a new avocado compound they say may open the door for better leukemia treatments.
More specifically, this compound appears to target and attack an enzyme that can be critical to cancer cell growth.
Researchers focused their attention on acute myeloid leukemia (AML), which doctors call the most dangerous variety of blood cancer. Most people diagnosed with AML are over 65 years-old and only about 10 percent survive for five years post-diagnosis.
Importantly, leukemia cells house large amounts of an enzyme called VLCAD that helps with metabolic processes.
“The cell relies on that pathway to survive,” says Dr. Paul Spagnuolo, Department of Food Science, in a university release. “This is the first time VLCAD has been identified as a target in any cancer.”
Is there a cancer treatment hiding in a superfood?
“Lo and behold, the best one was derived from avocado,” Spagnuolo notes.
“VLCAD can be a good marker to identify patients suitable for this type of therapy. It can also be a marker to measure the activity of the drug,” he continues. “That sets the stage for eventual use of this molecule in human clinical trials. There’s been a drive to find less toxic drugs that can be used.”
Right now, about half of all older AML patients enter palliative care. Others opt for chemotherapy, but that often does more harm than good.
“We completed a human study with this as an oral supplement and have been able to show that appreciable amounts are fairly well tolerated,” Spagnuolo concludes.
(That’s P as in “pantyhose”). Our daughter B posed this question recently and I had to resort to the Internet for advice.
My impression is that pantyhose in any way, shape, or form are considered frumpy and outdated. However, once one attains a certain age, splotchiness, or belly size, they can be more flattering than going au naturel. Also, consider the effect of goosebumps in cold weather.
No less an authority than Chanel is showing fishnet hose, a compromise I like. But first, here’s definitive advice from the NY Times fashion pages.
Does Anyone Wear Pantyhose Anymore?
Vanessa Friedman, fashion director of The New York Times, takes reader questions. This is from 2/26/2021.
My daughter is getting married this spring. It will be a small daytime wedding in a park. I bought a knee-length wrap dress and neutral-colored low heels to wear, and though I have not bought or worn stockings in decades, I feel as if I should wear them with this outfit. My daughter is horrified and plans to go barelegged under her knee-length wedding dress. Is there a general “rule” about stockings? Some guidance, please. — Judith, Washington, D.C.
Pantyhose — or stockings or nylons or tights, which are not exactly the same things but are often used interchangeably — are one of those items of dress that seems innocuous and unimportant, but is actually a giant generational, occupational and cultural lightning rod. For women of a certain age, they are simply a part of girding yourself for the world; for others, they are a symbol of old-fashioned female repression and outmoded gender rules.
They’re not exactly a girdle or a crinoline, but they are a descendant of that genetic line: undergarments foisted on women to cover their bodies and make them “acceptable” to outsiders. They also, of course, help keep your legs warm and maybe prevent skirts from clinging, but that’s the trade-off.
Indeed, if you ever want to start a lively discussion during a lull in a dinner party, bring up the question of pantyhose. Even when they are invisible or skin-tone, no one is neutral on the subject.
Simply consider, if you will, the case of Megan Markle. Just after her wedding, when she was still a sign of change within the royal family and hopes were high for modernization, she appeared with her new in-laws at Prince Charles’s 70th birthday party in an ivory dress, matching hat and pale hose! The internet freaked out, with numerous viewers seeing in the tights a sign that she was being stifled, just as her legs were stifled.
Indeed, there were lots of rumors that tights were royal protocol, in part because the Duchess of Cambridge, like her grandmother-in-law, always wears them. Yet a few months after the tights appearance, Ms. Markle put an end to the talk, attending a charity performance in a tuxedo minidress and … no hose! Revolution, cheered the watching hordes.
Whatever the truth of the royal issue, the import was pretty clear: Stockings are not modern.
This fall into disrepute has probably been hastened by the pandemic, since pantyhose are not exactly a necessary part of one’s wardrobe when working from home. And indeed, even before remote work became a reality for many of us, most offices had abandoned the requirement (spoken or not) for pantyhose at work.
The exception being flight attendants. For many of them, pantyhose are still part of the uniform — see Kaley Cuoco in “The Flight Attendant” on HBO Max — in part because the compression in some pairs helps with circulation at altitude.
That said, designers love to reinvent and reassess previously rejected garments, so right on cue stockings have been on the rise in a variety of collections. Virginie Viard put sheer polka-dot versions on her runway for fall 2020; they were there at Saint Laurent in lace; and this week Kim Jones showed a sheer black pair at his Fendi show.
All of which means: It’s up to you. But understand what messages the outside world may read into your choice.
If you do choose to go with the hose, some brands to consider include Hipstick and Commando, both favorites of the Hollywood crowd. (Yes, there is a lot of hosiery on the red carpet.) Nubian Skin offers a variety of shades that actually work for the actual variety of skins. For a splurge, there’s Wolford, which is the Duchess of Cambridge’s go-to brand. Finally, on the more affordable end of the scale, there is Hanes, which is a top-seller on Amazon.
And know this: The sheer nylons and tights segment of the global hosiery market is predicted to grow by 2.1 percent over the next seven years. So whatever the politics, pantyhose are not going away.
TORONTO, Ontario — Have you been putting off your spring cleaning or just saving some tedious chores for a rainy day? A new study may provide the motivation you need, especially for seniors. Researchers in Toronto find older adults who perform household chores have larger brains — a key measure of good cognitive health.
“Scientists already know that exercise has a positive impact on the brain, but our study is the first to show that the same may be true for household chores,” says Noah Koblinsky, lead author of the study, Exercise Physiologist and Project Coordinator at Baycrest’s Rotman Research Institute (RRI) in a media release.
“Understanding how different forms of physical activity contribute to brain health is crucial for developing strategies to reduce the risk of cognitive decline and dementia in older adults.”
Researchers at Baycrest Hospital examined 66 mentally healthy older adults during their study. Each participant took part in three assessments, a health evaluation, structural brain imaging, and a cognitive test. Results reveal older people who spend more time doing chores have greater brain volume, regardless of how much they exercise. These chores ranged from cleaning, to cooking, to going outside and working in the yard.
How do chores keep the brain healthy?
Although most people probably aren’t fond of doing chores, the team finds they’re likely helping the brain in several ways. First, study authors believe chores have a similar effect as low-intensity aerobic exercise — which benefits the heart and blood vessels.
Chores also push the mind to plan and organize, which promotes the formation of new neural connections over time. Lastly, researchers say chores help older adults become less sedentary. Previous studies have revealed how sitting and being less active can lead to poor health and cognitive decline.
“Besides helping to guide physical activity recommendations for older adults, these findings may also motivate them to be more active, since household chores are a natural and often necessary aspect of many people’s daily lives, and therefore appear more attainable,” says senior author Dr. Nicole Anderson, Senior Scientist at the RRI.
Now that travel restrictions have eased a bit, and we’re all looking forward to a proper getaway, the following article from AllTimeLists is very timely.
To which I’ll add my own pet peeves:
Passengers who lean way back in their seats, oblivious to the discomfort of those behind them.
Bringing smelly food on board.
Loud conversations, especially with your companion three rows away.
Frequently blocking the aisle to get something out of the overhead. Just pack what you’ll need for the actual flight (book/meds/moisturizer/hand sanitizer/tablet), stick it under your seat and sit the f*** still.
Removing your mask whenever you think nobody’s looking.
Stowing your small carry-on in the overhead bin. How many times do they have to announce this??
Singing along to what’s on your headphones. Yes, we can hear you and it’s not pretty.
8 Things Flight Attendants Wish They Could Tell Passengers
Remember when air travel was fun and easy? Neither do we, but rumor has it; there was a time when flying was not the pressure cooker it is today.
The air traveling process can produce quite a bit of stress. Imagine it being your full-time job. Flight attendants have the tough task of tending to an entire plane full of people—each passenger with different complaints and needs.
Continue reading to find out what flight attendants wish they could tell their passengers.
8.”Not Taking off Hurts Us, Too”
Flight attendants want to take off on time too. I mean, you are all going to the same place after all. People tend to be overly rushed for no reason. Patience and kindness go a long way!
Also, flight attendants do not get paid while the plane is sitting at the gate. Flight attendants get paid for “flight hours only.” Meaning that the clock doesn’t start until the craft pushes away from the gate. Flight delays, cancellations, and layovers affect them just as much as they do passengers – maybe even more.
Airlines aren’t completely heartless, though. From the time they sign in at the airport until the plane slides back into the gate at their home base, they get an expense allowance of $1.50 an hour.
7.”Don’t Walk in the Aisle Without Shoes”
Aside from the fact that doing this announces to the entire flight that you are the most arrogant, self-centered creature ever to set foot on an airplane, it’s also unsanitary.
“I think people don’t realize how dirty the planes are,” said a flight attendant for PSA Airlines, an American Airlines Group subsidiary. He said that while flight attendants pick up trash between flights, the planes receive a thorough cleaning once a day.
6.”Cut Us Some Slack”
It really makes no sense why some passengers can be so abusive to the flight crew. The flight attendants did not cause the rotten weather that delayed the flight, the unruly behavior of the person behind you, the congestion at the destination airport, or almost anything else you are screaming at the flight attendant about. Please show them some compassion!
5.”We are Not Mind-Readers”
You know the old proverb about what happens when you assume, right? So don’t fly off the handle because the crew didn’t fulfill an expectation of yours that you didn’t verbalize. Keep in mind that these are flight attendants, not your siblings or parents.
Flight attendants can not read your mind. Have some patience! They can’t tailor service to every person, and people sometimes people forget that.
4.”Take Responsibility for Your Actions”
“I just wish I could tell passengers, ‘Be more responsible for yourself,’” a flight attendant for American Airlines said. Next time you are on a flight and have issues you caused yourself, take accountability for your actions. Be more responsible! Also, to go along with the no-shoes item, responsible behavior means respecting everyone else on the flight.
Clipping your toenails, snoring so loud you can be heard on the ground 35,000 feet below, or doing personal business under a blanket, should never be done on a plane. Remember, this is an airplane, not your house. This is a public space, not a private one. Respect the existence and rights of others.
3.”Don’t Ask if a Delay Will Result in a Late Arrival”
There is a difference between a pilot and a flight attendant. They have been trained to fulfill different roles, and one is not able to perform the duties of the other.
In the case of delayed flights, the flight attendant won’t know any more than you. They won’t know if the flight’s lost time can be made up during the flight or if it will result in a late arrival. So, don’t get annoyed when you ask them, and they don’t have an answer. In fact, don’t bother asking at all.
2.”You Have Never been in Extreme Turbulence”
More than 2 million people fly in the United States each day, and yet since 1980, only three people have died as a direct result of turbulence. Of those fatalities, two passengers weren’t wearing their safety belts.
During that same time period, the Federal Aviation Administration recorded just over 300 serious injuries from turbulence, and more than two-thirds of the victims were flight attendants. What do these numbers mean? As long as your seat belt is on, you’re more likely to be injured by falling luggage than by choppy air.
Speaking of falling luggage, don’t try to game the system by wrapping twine around your refrigerator and calling it carry-on luggage and only get about half of it inside the overhead bin.
One of the easiest ways to earn the ire of a flight attendant is to put your carry-on in a full overhead bin, leave it sticking out six inches, then take your seat at the window and wait for someone else to come along and solve the physics problem you just created. Measure your bag at home before you pack it a carry-on.
A carry-on bag’s typical dimensions are 9 inches x 14 inches x 22 inches (22 cm x 35 cm x 56 cm), including handles and wheels. If yours is bigger, check it in. Yes, the checked bag fee is a pain, but your huge item is creating an injury risk for yourself and everyone around you.
MELBOURNE, Australia — From someone experiencing chest pain after a breakup, to a married couple dying within minutes of each other, there are many real examples of what doctors call broken heart syndrome. While the emotional scars are a separate issue, there may finally be a way to prevent lasting physical injury. Researchers in Australia say, for the first time, scientists have uncovered a drug that can literally mend a broken heart.
A team from Monash University find Suberanilohydroxamic acid (SAHA) can significantly improve cardiac health due to this condition. In their study, researchers used SAHA to target genes affected by a “broken heart” — or Takotsubo cardiomyopathy.
Although many may think broken heart syndrome is just a saying, doctors know it to be a very real ailment. Patients suffer a weakening of the left ventricle, the heart’s main pumping chamber. Stressful emotional triggers, usually following a traumatic event like the death of a loved one, often cause this problem. Researchers add broken heart syndrome can mimic a heart attack, causing chest pain, shortness of breath, and an irregular heartbeat.
How does SAHA heal the heart?
Suberanilohydroxamic acid is currently serving as a cancer treatment, with the U.S. Food and Drug Administration approving its use. The drug works on the heart by protecting certain genes and the acetylation/deacetylation (Ac/Dc) index in particular. This is a vitally important process which regulates gene expression in humans.
“We show for the first time a drug that shows preventative and therapeutic benefit is important to a healthy heart. The drug not only slows cardiac injury, but also reverses, the damage caused to the stressed heart,” says study leader Professor Sam El-Osta from Monash Central Clinical School in a university release.
Mostly women suffer from this mysterious condition
The study finds, in western nations, broken heart syndrome almost exclusively affects women, especially after menopause. In fact, researchers say up to eight percent of women believed to be having a heart attack may actually be dealing with Takotsubo cardiomyopathy.
While the symptoms are similar, the exact cause of the physical pain of a broken heart is still a mystery. Doctors believe a surge of stress hormones flood the heart during a traumatic event. This may cause changes in the heart muscles and blood vessels which prevent the left ventricle from working properly. The result is the heavy, achy feeling people get in the chest that can be mistaken for a heart attack.
The good news is most people recover from broken heart syndrome within two months. The bad news, unfortunately, is that some patients may suffer from heart failure due to their extreme trauma. Although death from a broken heart is rare, researchers say 20 percent of patients experience some degree of heart failure. Until now, there has been no standard treatment to alleviate this condition.
“This pre-clinical study describes a new standard in preventative and therapeutic potential using a cardioprotective drug that targets genes in the heart,” Professor El-Osta concludes.
“The team is committed to the research of women’s health recognizing the uneven sex prevalence of almost 9:1 (female to male). Based on these promising results we are focused on the continued development of compounds like SAHA to improve cardiac benefit and healthier life.”
For weeks, I’d been dreading this: several days in Austin to clear out our remaining belongings — we’d sold the house in late March –, sell two cars, close our safe deposit box, and then drive 3-4 days back to Oregon.
Luckily, we were able to accomplish said tasks quickly, ship the boxes instead of loading them into our Titanic-sized, impossible-to-park rental car, and fly back instead. As I’ve often remarked, there is almost no problem that can’t be solved by throwing money at it. (Though, to digress, this apparently hasn’t worked for Bill and Melinda Gates.)
This allowed us time to visit with family and friends and reflect on some of the unexpected pleasures of dining out during a pandemic.
Pandemic Travel 2.0
Waitstaff no longer hover over your table, telling you their life story (“Hi, I’m Bruce and I’ll be your server tonight, although I’m really an actor and I’ve written this cool sci-fi script…”).
Table spacing makes for a much quieter experience. You might even be able to hear your own conversation.
Maybe it’s an illusion, but everything just seems cleaner.
Silverware arrives wrapped in a napkin, rather than having been sitting out on the table.
Many restaurants have streamlined their menus, so the choices are better thought-out and fresher.
People are too far away to eavesdrop.
As for air travel,
Fewer travelers = speedier security. They sure want you to keep moving.
Nobody seems to worry about liquids anymore.
Better filtration = less chance of catching a cold or flu, never mind COVID.
Even anti-maskers have to wear one.
A discreet cough or two (into your mask of course) and no one will attempt to ask what you’re reading or whether you live at your destination.
Fewer travelers = less luggage. For the first time in recent memory, our checked bags were already at the carousel by the time we arrived at baggage claim.
Woo hoo — home sweet (temporary) home in one day, not four. So what if we’ll have to load 17 boxes into our car and lug them to a new (also temporary) storage unit; the kids can sort out our crap when we cross the rainbow bridge!
BRAGA, Portugal — It’s no secret that shot of caffeine from a morning coffee can give many people a quick boost. Now, a new study finds going for that second and third cup may be good for your brain. Researchers in Portugal say people who regularly drink coffee are not only more alert, but see more activity in their brains as well.
According to the European Food Safety Authority, moderate coffee consumption is typically three to five cups per day. In the new study, researchers from the University of Minho reveal consuming this much caffeine each day can make coffee drinkers more focused while also displaying greater memory and learning abilities.
Scientists examining MRI scans discovered differences in the makeup of the brains between regular coffee drinkers and those who don’t consume the beverage at all. Coffee drinkers had a more “efficient” brain, with quicker connectivity in the cerebellum, the right precuneus, and the right insular.
Even one cup of coffee can keep you sharp
These patterns show regularly drinking coffee may give people better motor control. Participants consuming caffeine were also less likely to let their minds wander. Study authors add the effects of this brain boost can be immediate. Results show non-coffee drinkers could start seeing benefits for a short time after a single cup of java.
Researchers studied the connectivity and structure of the brain in 31 regular coffee drinkers and 24 non-coffee drinkers while at rest. The team also examined these individuals while they performed a mental task soon after consuming a cup.
“This is the first time that the effect that drinking coffee regularly has on our brain network is studied with this level of detail,” says Professor Nuno Sousa in a university release. “We were able to observe the effect of coffee on the structure and functional connectivity of our brain, as well as the differences between those who drink coffee regularly and those who do not drink coffee in real time.”
“The findings help to understand improving the effects of caffeine, highlighting improved motor control, increased levels of attention and alertness, and benefits in learning and memory,” Prof. Sousa’s team concludes.
NEW YORK — Will a bad choice at the bar sink your budding romance? Three in ten Americans say they’ve ended a date early because of what their date ordered to drink, a new study reveals.
The survey of 2,000 Americans over 21 who consume alcohol finds the first drink on a date makes a lasting first impression. Sixty percent of men in the poll agree a bad drink order would be a “deal-breaker” for them. Just 32 percent of women, however, said the same.
Top shelf dating advice
Want to win someone over right away? Take a page out of James Bond’s playbook. Three in five said a martini will make the ultimate good impression. The other drinks that leave potential partners impressed include gin and tonics (46%) and Manhattans (45%). Forty-two percent would look favorably on a date who orders a Cosmopolitan or a Whiskey Sour.
On the other hand, the drink most likely to make a bad first impression is a Long Island Iced Tea, with 22 percent saying that’s a dating deal-breaker. With so much pressure on that initial drink order, it’s no wonder over a third (37%) order a “fancy” drink while on a date.
The survey, conducted by OnePoll on behalf of Jack Daniel’s, also reveals 62 percent think a person’s drink of choice says “a lot” about their personality. It’s for that reason two in three respondents (65%) think people should order their drink of choice on a first date to showcase who they “really are.”
The results also find four in five (79%) have a “go-to” drink that took them three years of experimenting on average to finally find.
With age comes (drinking) wisdom?
It’s not just about what goes in the drink, though, as 71 percent claim to be experts who know how to prepare their drink “the right way.”
Over half the poll actually consider themselves a “connoisseur” in their spirit of choice, but that wasn’t always the case. The average person “graduated” from low to top-shelf taste at 27 years-old and needed three years to become truly knowledgeable about their favorite spirit.
“Your drink of choice says a lot about your personality and it’s no surprise to us that classic whiskey cocktails have never gone out of style. However our friends choose to enjoy our Tennessee Whiskey, we want them to do so responsibly,” a spokesperson for Jack Daniel’s says in a statement.
The company commissioned this survey in honor of International Whiskey Day and wanted to find out just what Americans love about the spirit. Three in ten named whiskey as their favorite type of alcohol.
When it comes to whiskey-centric cocktails, drinkers say simple is better. Whiskey-colas come in as the top choice for a third of respondents. Whiskey Sours (31%), Irish Coffees (23%), and an Old Fashioned (23%) followed closely behind on the menu.
“Whiskey has always been a staple in any home bar. All of the classic whiskey cocktails that were identified by the respondents can easily be perfected at home and with the seasons changing it’s the ideal time to experiment with new recipes,” the spokesperson for Jack Daniel’s ads.
Going to ‘Dr. Google’ to look up your symptoms actually leads to accurate diagnoses!
BOSTON, Mass. —The moment something doesn’t look or feel right, many people won’t run to their doctor, they’ll turn to Google. Although an internet search may not sound like good medical advice, a new study finds it can actually help. Researchers say patients who use “Dr. Google” to find out what’s wrong with them will likely get the right diagnosis.
According to the report, googling symptoms improves peoples’ ability to diagnose their illness without adding additional stress. Researchers from Brigham and Women’s Hospital and Harvard Medical School admit that “cyberchondria” has made the value of internet medical searches controversial.
This increased anxiety brought on by continuously looking up every ailment online has even pushed some medical professionals to urge patients not to look their symptoms up online before seeing them. Researchers add anxiety can lead people to think they’re on death’s door when in fact they are perfectly healthy.
Despite Dr. Google’s poor reputation, study authors conclude using the internet to check your symptoms may not be such a bad idea after all.
“I have patients all the time, where the only reason they come into my office is because they Googled something and the Internet said they have cancer,” study author Dr. David Levine says in a media release. “I wondered, ‘Is this all patients? How much cyberchondria is the Internet creating?”
Can everyday people give out sound medical advice?
Researchers asked 5,000 participants to read a short “case vignette,” describing a number of symptoms and imagine someone close to them was experiencing them. The participants then had to make two diagnoses, before and after looking up the symptoms online.
Cases ranged from mild to severe, but described common illnesses, such as viruses, heart attacks, and strokes. Study authors also asked the group to choose between letting the health condition get better on its own or calling 911. After making their choice, participants reported how anxious they felt.
Results reveal participants were “slightly better” at correctly diagnosing their cases after carrying out an internet search. The process also did not add to their levels of anxiety.
“Our work suggests that it is likely OK to tell our patients to ‘Google it,’” Dr. Levine says. “This starts to form the evidence base that there’s not a lot of harm in that, and, in fact, there may be some good.”
Are robot doctors next?
The team admits it’s not clear whether people would behave the same way if one of their loved ones was truly ill. Moreover, the results won’t represent the reactions of all people who use the internet for health-related searches. Next, study authors are planning on testing whether artificial intelligence could use the Internet to correctly diagnose patients.
“This next study takes a generalized AI algorithm, trained on all of the open-source text of the Internet such as Reddit and Twitter, and then uses that to respond when prompted,” Dr. Levine concludes. “Can AI supplement how people use the Internet? Can it supplement how doctors use the Internet? That’s what we’re interested in investigating.”