Tag Archives: skin care

Good News Monday: Preventing Wrinkles AND Cancer?

Here’s another reason to take care of our complexions: New research finds that increased collagen helps fight cancer. While topical creams may or may not make much difference (dermal penetration is minimal), treatments that build collagen such as Genesis and IPL (intense pulsed light) may do more than keep that youthful glow. Schedule that derm appointment STAT!

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Anti-wrinkle cream ingredient collagen could hold the key to curing cancer

NEW YORK — A substance that the body creates naturally and is also an ingredient in anti-wrinkle creams could hold the key to stopping the spread of cancer. Researchers from The Tisch Cancer Institute at Mount Sinai say cancerous tumors secrete a form of the protein collagen that keeps them quiet for years, even as they spread to other parts of the body. Their findings reveal that these tumor cells only turn malignant once their supplies of collagen run out.

Experiments involving mice and humans found increasing levels of type III collagen — the form of the protein cancer cells produce and cover themselves in — stops diseased cells from spreading. The collagen that surrounds the cells forces them to remain in a dormant state, preventing recurrence and metastasis — where they migrate to other organs.

“Our findings have potential clinical implications and may lead to a novel biomarker to predict tumor recurrences, as well as a therapeutic intervention to reduce local and distant relapses,” says senior author Professor Jose Bravo-Cordero in a media release.

Using state-of-the-art scanning techniques, the team tracked breast, head, and neck cancer cells implanted in mice. This enabled them to visualize the supporting “scaffold” as they became dormant and how this covering changed as the cells awoke.

Covering tumor cells in collagen could keep cancer asleep

In samples from cancer patients, researchers found type III collagen predicted tumor recurrence and metastasis. In the mice, infusions of collagen around cancer cells blocked their progression, forcing them back into dormancy.

“This intervention aimed at preventing the awakening of dormant cells has been suggested as a therapeutic strategy to prevent metastatic outgrowth,” Prof Bravo-Cordero says.

“As the biology of tumor dormancy gets uncovered and new specific drugs are developed, a combination of dormancy-inducing treatments with therapies that specifically target dormant cells will ultimately prevent local recurrence and metastasis and pave the way to cancer remission.”

How cancer cells remain inert for long periods before awakening to wreak havoc throughout the body has baffled experts for decades. The study, published in the journal Nature Cancer, solves a major mystery and opens the door to therapies using collagen as a cancer treatment.

From cosmetics to cancer research

Most people likely know collagen for its use in helping people look younger. However, the protein is also a natural building block for the skin, bones, and connective tissues throughout the body. It provides strength and elasticity, but women experience a dramatic drop in production after menopause.

In cosmetic products, collagen injections can improve the contours of the skin. Fillers that contain collagen remove lines and wrinkles from the face. It can also improve the appearance of scars.

Study authors note that collagen is present in the extracellular matrix, an intricate network that determines the physical properties of tissues — including tumors. Most cancer deaths are due to these harmful cells spreading throughout the body, which can still happen several years after surgical removal of the original tumor.

Previous research has shown collagen dressings heal chronic wounds that do not respond to other treatments. Encasing a tumor in collagen may have similarly dramatic success, Prof. Bravo-Cordero explains.

The study author adds that wound treatment with collagen scaffolds has displayed promising results and is a therapeutic alternative for people with complex skin wounds.

“Our studies demonstrate the potential therapeutic use of type III collagen to prevent the reawakening of cancer cells by inducing and maintaining cancer cell dormancy in the primary site,” researchers conclude in a statement to SWNS.

South West News Service writer Mark Waghorn contributed to this report.

What’s Your Black Hole?

I’ve been seeing a lot of blogs recently about decluttering, a topic that’s near and dear to my post-move heart.

Now that most things are neatly stored away, I sometimes forget what I already own. This leads to embarrassing discoveries when I buy something and realize later that I already have more of the same or similar — often in multiples.

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My particular nemesis is skin care, especially bath products.  For some reason I can’t resist new ones.  Is it because these luxuries are relatively inexpensive? Because of the implied promise of silkier skin, relaxation, leisure, stress relief, or dare I say even a more youthful appearance?

From now on, I’m going to try to remember to check all those carefully labeled storage bins before I succumb to the siren call of another new lotion, potion or emotion.

Does anyone else have this, er, problem?

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Beauty Adventures: Vanity and Necessity

This getting older thing seems to require ever-greater vigilance. The wear and tear of sun exposure and general activity caught up with me recently, resulting in a few rounds of sclerotherapy and in-office surgery for a squamous cell (non-melanoma) carcinoma.

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Prominent veins are much prettier on leaves

First, the vanity part: sclerotherapy.

I’ve made peace with my legs’ freckles, moles, scars and other mementoes of time but one thing was really bothering me: clusters of ugly spider veins around my ankles that had appeared over the past few years. (Thanks, gravity!)

Since boots are not a year-round option and the distracting power of red nail polish only goes so far, I finally decided to do something.

Sclerotherapy is commonly used to treat varicose veins or spider veins. Depending on the types of veins affected, lasers and other methods may be indicated. In my case, sclerotherapy was the recommendation and – spoiler alert – it has made a difference.

The procedure is non-surgical, doesn’t require anesthesia, and, in most cases, doesn’t require any special preparation. Your doctor injects a solution (called a sclerosant) into the blood vessels or lymph vessels, which causes them to swell and cut off the flow of blood or lymphatic fluid to the veins, which in turn makes them shrink. The practitioner can actually see them disappear – how cool is that?

During the treatment, you lie on your back with your legs up. After cleaning the area, the doctor injects the vein with the irritant. You may feel burning, tingling, or nothing at all. In my case there was some stinging but it wasn’t too bad. When the injection is complete, the doctor massages the area to prevent blood from re-entering the vein. Depending on the area being treated compression socks may be helpful afterwards.

After treatment, you need to remain active to prevent blood clots from forming, and avoid sunlight, which can cause dark spots at the treated area. Other than some soreness, redness and bruising at the injection site, recovery is easy.

 Research suggests that sclerotherapy effectively removes spider veins in 75-90% of cases, but typically requires multiple treatments. It took me 3 sessions to remove all but the most visible cluster, which has not gone away completely but is much lighter. Unfortunately, the procedure isn’t covered by insurance and since standing and walking put pressure on the veins, they’ll probably come back eventually.  I’m hoping it takes a few decades.

Necessity: skin cancer prevention

Being fair-skinned and paranoid, I’m vigilant about sun block and see my dermatologist annually for a full-body skin check. This time, I called her attention to a small but tenacious spot on the back of my hand and she agreed that a biopsy should be done. Most red spots resolve within a month (a bit longer as we get older and our skin takes more time to heal). Anything that doesn’t go away should be evaluated.

Turns out I had a squamous cell non-melanoma carcinoma, the second most common form after basal cell carcinoma. Not life threatening, but not something you want to ignore, either. We scheduled surgery for a couple of weeks later.

Skin cancer is the most common of all cancers; each year in the U.S. nearly 5 1/2 million cases of non-melanoma skin cancer are treated in more than 3.3 million people. It’s also the easiest to cure when diagnosed and treated early. The head (particularly if you have thinning hair), face, tops of the ears and back of the hands are especially vulnerable. Hats and gloves, people! And wear sun block every day, including driving and swanning about in your corner office with the big windows!

Dermatologists used to focus on brown, unevenly shaped or mottled moles. But scientists have now learned that melanomas can also be pink or red. Be on the lookout for areas that are rough, red and raised. Often you’ll detect anomalies more by feel than by the way they look.

Pre-op: The biopsy has removed most of the problem already, since squamous cells are in the top layer of skin. The pre-op prep includes avoiding blood thinners such as ibuprofen, certain supplements and alcohol the week before, plus cleaning the area in advance with an over-the-counter antibacterial liquid.

Day Of: First, the surgical area is numbed with a lidocaine injection. Mine is on my wrist so the incision is lateral and should be hidden by all the other creases. Surgery isn’t painful and I only need acetaminophen a couple of times in subsequent days.

A Week (Plus) Later: A nurse at the derm’s office removes the stitches and applies three Steri-Strips. These fall off after another week. Three weeks post-op, the back of my hand is still sore and puffy but is slowly improving.

After-care: Dr. D recommends Gold Bond Strength and Resilience to moisturize skin, Anthelios 60 sunscreen, and Serica for scar improvement – it’s much easier to apply this gel than bulky scar strips. I’m also trying it on last year’s bunion scar to see if it helps.

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Dr. D has also suggested I try nicotinamide (B3) supplements. In the recent ONTRAC study, oral use significantly reduced the risk of melanoma in patients who’d had two or more precancerous basal or squamous lesions.

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I’m taking 500 mg twice a day and will start seeing my derm twice a year from now on. I’ll also be ordering Anthelios by the truckload.

 

“Anti”-Aging

Allure magazine has recently reported that they’ll no longer use the term “anti-aging”. It’s about time.

Since we’ve only got two options — getting older or checking out — there’s not much point in fighting the inevitable. Instead, let’s embrace some of the positives and enjoy being our best selves.

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Antiques are so much more interesting than newbies!

The List

1. YOUR DOUBLE CHIN DISAPPEARS. With the passing years, fat pads under our chins usually get smaller as our faces become less round. (Bonus: more visible cheekbones!) So if you’re considering a fat removal procedure in your 20’s or 30’s, you should probably wait.

2. YOU’RE HAPPIER. According to a study in the Journal of Clinical Psychology, happiness steadily increases from your 20’s to your 90’s as anxiety, depression and stress levels tend to go down.

3. YOU CAN WAVE GOODBYE TO THE BAGS UNDER YOUR EYES. When we’re younger, these are often fatty deposits. In older women, they’re more likely caused by fluid retention, which decreases as we go about our day.

4. SEX IMPROVES. Caveat: The study they cite in the magazine contrasts higher levels of satisfaction for women in their 40’s and 50’s vs. women in their early 20’s. Older women know their bodies better, are more likely to ask for what they want, and may be more spontaneous. (Note: no mention of post-menopausal issues, though.)

5. YOUR SKIN IS GLOWIER. Again, they’re talking 30’s-50’s, when moisture levels are highest and problems such as acne tend to resolve themselves. Moisture levels drop as hormones and hydration decrease, so 60+ skin often needs extra help.

6. YOU’LL SAVE ON WAXING. As testosterone dips in your 40’s, body hair starts to be lighter and thinner. Post-menopause, skin becomes thinner and waxing may be more irritating than a gentler process such as sugaring. Or, fuhgeddaboudit.

7. YOU’RE MORE OPEN-MINDED. A University of Michigan study found that women in their 50’s were more empathetic than those who were younger. Mature people may have strong opinions but we’re also more likely to understand other points of view.

For more thoughts on aging, plus a delicious cocktail recipe, click here.

 

 

Beauty Round-Up

As a public service to those of you who don’t have the time, inclination, or mind-numbingly long plane flights to read magazines, here are seven items that caught my eye recently.

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  • A hot bath burns as many calories as a 30-minute walk. This one really resonates with my inner sloth.
  • Cure for cellulite? The BelleCore Body Buffer, $149, is said to reduce water retention while buffing the skin to release tension and stretch the tough tissue that holds fat cells in place, creating that dreaded dimpled effect. I’d try it myself except that 1) I’ve spent far too much money this month, and 2) my butt and thighs are already flawless. Yeah, right.
  • The Big Five ingredients we need to improve our skin:
    1. Vitamin C, the powerful antioxidant that supports healthy collagen and fights free radicals that break it down. Check the concentration; anything cheap probably has too little to be effective.
    2. Retinol, the “miracle” ingredient that fights acne, smooths and reduces wrinkles and works wonders on sun-damaged skin. Best used at night and be sure to use sunscreen daily.
    3. Hyaluronic Acid (HA), which acts like a sponge to pull moisture from the air into the skin. Caveat: In a really dry climate, it can work in reverse, so slather on a rich moisturizer on top to prevent water loss.
    4. Alpha Hydroxy Acids (AHAs) such as glycolic acid increase cell turnover and inhibit enzymes that destroy collagen and elastin to treat fine lines, dullness and blackheads. Without SkinMedica’s GlyPro line, I’d probably look about 80.
    5. It may seem counterintuitive but oils work on both oily and dry skin. On oily complexions, face oil can signal the skin to stop overproducing sebum. For dry skin, layer oil over your HA serum and massage it in. Look for one that’s cold pressed (like a good olive oil) because heat can destroy its active properties.
  • A cluttered environment decreases self-control, increasing the likelihood of impulsive spending, according to a study in the Journal of Consumer Research. I’m cleaning up my desk RIGHT THIS MINUTE.
  • More vitamin D correlates with longer telomeres, the protective DNA sequences at the end of chromosomes. Shortened/broken telomeres are linked to blotchy skin, grey or thinning hair, deep wrinkles and other age-related consequences. Salmon, anyone??
  • Layer skin care products in order of “heaviness”. After cleansing and drying your skin (to reduce potential irritation), pat on your serum and let it dry before you layer on anything else. Next, massage in your facial oil. Then apply a rich moisturizer to lock in hydration. Sunscreen is your final product during the day, of course.
  • Tips for growing stronger nails:
  1. File in one direction from the outside to the center on both sides, using a file with 240 to 600 grit. Never metal.
  2. Don’t peel off your gel manicure or chipped polish. But you already knew that.
  3. Dry nails are more likely to break. Rub lotion and cuticle oil in throughout the day to get blood flowing and help stimulate cell regeneration.
  4. An almond shape is the strongest.
  5. According to dermatologists, the only supplement proven to work is biotin (2.5 mg/day, but check with your own doctor). Some recommend MSM, a form of sulphur, to help bind keratin in hair and nails.
  6. It takes six months for a nail to regrow.

By the way, people who make their bed in the morning are 19% more likely to get a good night’s beauty sleep.

Stay gorgeous! xx