Anti-aging protein discovered in blood prevents mental decline
JUNE 20, 2021by Chris Melore
HOUSTON, Texas — Anti-aging treatments are a popular field of study these days, as more and more people are living into their 70s and 80s. However, a new study reveals the answer to preventing cognitive decline as we age may have been sitting in our blood all along. Researchers have discovered a protein in red blood cells which has the power to prevent memory loss and other age-related issues in the brain.
Tests in mice find that removing the protein adenosine receptor A2B (ADORA2B) from red blood cells triggers faster declines in memory, the ability to recognize sounds, and leads to higher levels of inflammation in the brain.
ADORA2B helps deliver oxygen to keep us young
It’s no secret that as the human body ages, people begin to slow down. With more people reaching old age in modern times, more people are developing age-related diseases like dementia. Study authors explain that the amount of oxygen in the blood also declines as people age.
They add that ADORA2B, a protein on the membrane of red blood cells, helps to release oxygen so the rest of the body can use it. With that in mind, an international team set out to see how large of a role ADORA2B plays in keeping the brain youthful and active.
Researchers engineered a group of mice which lack ADORA2B in their blood. They compared these animals to normal mice, examining their mental decline as they got older. Results reveal all of the typical signs of cognitive decline — poor memory, hearing problems, and brain inflammation — were worse in mice lacking ADORA2B protein.
Moreover, after experiencing a lack of oxygen throughout their bodies, study authors discovered that behavioral and physiological trauma to mice without the anti-aging protein was more severe than in normal mice. Due to these findings, scientists conclude that ADORA2B slows the natural aging of the brain by delivering oxygen vital to its normal functioning.
“Red blood cells have an irreplaceable function to deliver oxygen to maintain bioenergetics of every single cell within our body. However, their function in age-related cognition and hearing function remains largely unknown. Our findings reveal that the red blood cell ADORA2B signaling cascade combats early onset of age-related decline in cognition, memory and hearing by promoting oxygen delivery in mice and immediately highlight multiple new rejuvenating targets,” says study author Dr. Yang Xia from the University of Texas McGovern Medical School in a media release.
The team published their findings in the journal PLOS Biology.